We are a research group in the Pathology and Laboratory Medicine and Human Genetics Departments in the David Geffen School of Medicine at UCLA. We are also affiliated with the Bioinformatics and Genetics and Genomics graduate programs, and the Jonsson Comprehensive Cancer Center at UCLA. We develop computational and statistical methods to understand the genetic basis of complex traits and diseases. We focus on methods for integrative genomics, fine-mapping and heritability. See our research projects and publications

 

 

 

 

 
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    Congratulations to Kangcheng, who graduated from Zhejiang University with a B.Eng in Computer Science! He will be joining the Bioinformatics PhD program at UCLA this fall.
    July 2019
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    New Paper! Our recent collaborative work examines the enrichment of breast and prostate cancer GWAS associations in regulatory regions across tissue types (Chen et al. 2019).

    Jun 2019
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    New Paper! In collaboration with the Ophoff Lab, we identify a novel risk locus for Dupuytren's disease and explore shared genetic etiology with BMI (Major et al. 2019).

    May 2019
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    Read our feature story in the newsrooms of the UCLA Jonsson Comprehensive Cancer Center and Cedars-Sinai!

    May 2019
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    Our latest work, in collaboration with Cedars-Sinai Cancer and Dana-Farber Cancer Institute, identifies 34 genes associated with an increased risk for developing the earliest stages of ovarian cancer.(Gusev et al. 2019).

    May 2019
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    Ruthie and Bogdan are giving talks at the 2019 Biology of Genomes in May!

    Ruthie: "Dissecting the genetic architecture of complex traits through local polygenicity using summary statistics from genome-wide association studies"

    Bogdan: "Accurate estimation of SNP-heritability from biobank-scale date irrespective of genetic architecture"

    April 2019
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    Two publications in the latest issue of Nature Genetics! FOCUS: fine-mapping TWAS to find causal genes (Mancuso et al. 2019).

    March 2019
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    Also in the latest issue of Nature Genetics, in collaboration with many, we present a perspective on the usage and interpretation of TWAS as a tool to find causal genes (Wainberg et al. 2019).

    March 2019
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    Congratulations to Nick, who will be joining the Center for Genetic Epidemiology and Department of Preventive Medicine at USC as a tenure-track assistant professor next month!
    March 2019
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    New Paper! An examination of 296,215 cases across 6 solid cancer types highlights some shared common germline genetic basis, suggesting that some cancers could be studied together to better understand the biological pathways that lead to cancer (Jiang et al. 2019).

    January 2019
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    New Paper! Our latest work with the Price Lab uses polygenic functional enrichment to incorporate coding, conserved, regulatory, and LD-related genomic annotations into association analyses (Kichaev et al. 2019).

    January 2019
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    Blog update: Read Ruthie's 7 Tips for making presentations, a compilation of quick tips that our lab finds useful when putting together presentations!
    December 2018
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    Arun presents his work on tissue-wise genetic subtyping of complex traits in the Genetics of Cardiometabolic Traits session at ASHG!

    October 2018
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    The lab attends ASHG 2018 in San Diego!

    October 2018
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    New Paper with the Arboleda Lab! Our quantification of the shared genetic basis between complex traits and Mendelian disorders is now published in AJHG (Freund et al. 2018). 

    October 2018
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    New Paper! Our latest TWAS for prostate cancer risk is now published in Nature Communications  (Mancuso et al. 2018). 

    October 2018
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    Kangcheng presents his poster on fixed effects models for heritability estimation at the CSST Summer Poster Session!

    Sept 2018
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    Arun's abstract on tissue-wise subtyping of complex traits is selected for a platform presentation at the American Society of Human Genetics Annual Meeting!
    August 2018
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    Congratulations to Dr. Megan Roytman for successfully defending her thesis!

    July 2018
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    Ruthie gives a talk on the UNITY framework at the Intelligent Systems for Molecular Biology annual conference in Chicago!

    July 2018
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    New Paper! (Johnson et al. 2018). Congrats to Ruthie for her work on the UNITY framework!

    July 2018
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    It's graduation day -- Drs. Kichaev and Shi await their diplomas!

    June 2018
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    TWAS hub is now live, offering searchable access to TWAS results from hundreds of complex traits and dozens of expression studies!
    June 2018
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    Nick and Malika earn fellowships at UCLA in the Neurobehavioral Genetics Training Grant and Biomedical Big Data Training Grant, respectively!
    June 2018
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    Congratulations on a successful PhD defense to our newly-minted Dr. Huwenbo Shi!

    May 2018
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    Malika's abstract is selected for an oral presentation at the UCLA Annual Joint Research Symposium!
    April 2018
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    Kathy earns a fellowship in the Genomic Analysis and Interpretation Training Program at UCLA!
    April 2018
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    When the fire alarm goes off during your PhD defense, you have to improvise! Congratulations to our own Dr. Gleb Kichaev!

    April 2018
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    New Paper! (Giambartolomei et al. 2018). Read our blog post about MOLOC!

    March 2018
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    New Paper! (Roytman et al. 2018). Read more from Megan on our blog post!

    February 2018
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    Blog update: Check out our latest post on Explaining missing heritability using Gaussian process regression by Huwenbo!
    February 2018
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    Blog update: Working with GWAS summary data? Read Huwenbo's tips for formatting and quality control to avoid pitfalls in post-GWAS analyses!
    February 2018
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    Blog update: Read Ruthie's post about CANVIS, a command line fine-mapping tool for visualizing fine-mapping studies.
    January 2018
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    New Paper! (Shi et al. 2017). Learn more about Rho-HESS on our blog!

    November 2017
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    Congratulations to Valerie for winning the NIH Director's Early Independence Award!

    November 2017
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    The lab attends ASHG 2017 in Orlando!

    October 2017
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    Congratulations to Malika for winning the Stephen D. Cederbaum ASHG Abstract Travel Award 2017!
    October 2017
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    Congratulations to Ruthie and Page for winning the UCLA Dean’s Prize for Excellence at the undergraduate Research Poster Day 2017!

    June 2017
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    Gleb wins Cotterman award for best trainee paper in AJHG 2015!

    October 2016
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