We are a research group in the
Pathology and Laboratory Medicine
Departments in the
David Geffen School of Medicine
. We are also affiliated with the
Genetics and Genomics
graduate programs, and the
Jonsson Comprehensive Cancer Center at UCLA
. We develop computational and statistical methods to understand the genetic basis of complex traits and diseases. We focus on methods for integrative genomics, fine-mapping and heritability. See our
The lab at ASHG 2018!
The lab at ASHG 2017
New Paper! Our latest work with the Price Lab uses polygenic functional enrichment to incorporate coding, conserved, regulatory, and LD-related genomic annotations into association analyses
(Kichaev et al. 2019).
Blog update: Read Ruthie's
7 Tips for making presentations
, a compilation of quick tips that our lab finds useful when putting together presentations!
Arun presents his work on tissue-wise genetic subtyping of complex traits in the Genetics of Cardiometabolic Traits session at ASHG!
The lab attends ASHG 2018 in San Diego!
New Paper with the Arboleda Lab! Our quantification of the shared genetic basis between complex traits and Mendelian disorders is now published in AJHG
(Freund et al. 2018).
New Paper! Our latest TWAS for prostate cancer risk is now published in Nature Communications
(Mancuso et al. 2018).
Kangcheng presents his poster on fixed effects models for heritability estimation at the
Summer Poster Session!
Arun's abstract on tissue-wise subtyping of complex traits is selected for a
at the American Society of Human Genetics Annual Meeting!
Congratulations to Dr. Megan Roytman for successfully defending her thesis!
Ruthie gives a
on the UNITY framework at the Intelligent Systems for Molecular Biology annual conference in Chicago!
(Johnson et al. 2018).
Congrats to Ruthie for her work on the UNITY framework!
It's graduation day -- Drs. Kichaev and Shi await their diplomas!
is now live, offering searchable access to TWAS results from hundreds of complex traits and dozens of expression studies!
Nick and Malika earn fellowships at UCLA in the Neurobehavioral Genetics Training Grant and Biomedical Big Data Training Grant, respectively!
Congratulations on a successful PhD defense to our newly-minted Dr. Huwenbo Shi!
Malika's abstract is selected for an oral presentation at the UCLA Annual Joint Research Symposium!
Kathy earns a fellowship in the Genomic Analysis and Interpretation Training Program at UCLA!
When the fire alarm goes off during your PhD defense, you have to improvise! Congratulations to our own Dr. Gleb Kichaev!
(Giambartolomei et al. 2018).
(Roytman et al. 2018).
Read more from Megan on our
Blog update: Check out our latest post on
Explaining missing heritability using Gaussian process regression
Blog update: Working with GWAS summary data? Read Huwenbo's
tips for formatting and quality control
to avoid pitfalls in post-GWAS analyses!
Blog update: Read
about CANVIS, a command line fine-mapping tool for visualizing fine-mapping studies.
(Shi et al. 2017).
Learn more about Rho-HESS on our
Congratulations to Valerie for winning the
NIH Director's Early Independence Award
The lab attends ASHG 2017 in Orlando!
Congratulations to Malika for winning the Stephen D. Cederbaum ASHG Abstract Travel Award 2017!
Congratulations to Ruthie and Page for winning the UCLA Dean’s Prize for Excellence at the undergraduate Research Poster Day 2017!
Gleb wins Cotterman award for best trainee paper in AJHG 2015!